A total of 22 SNPs showed nominally significant association ( p <0.05) with at least one lipid trait in at least one ethnic group, although not always with the same lipid traits reported as genome-wide significant in the original GWAS.
In addition, because we compared our results to those obtained in large GWAS and meta-analyses that included several thousand subjects, we have also discussed the results of the SNPs that showed a trend (p-values between 0.05–0.20) for ‘the same direction’ of association with ‘the same genome-wide significant lipid trait’ reported in the original GWAS.
We also included 4 additional SNPs (shown in italics in Table 2 ) that although did not reach genome-wide level of significance for HDL-C [7] , [8] , they were either highly significant for HDL-C or modestly significant for HDL-C but genome-wide significant for at least one of the three other lipid traits (TC, LDL-C or TG).