Novel alterations in the epigenetic signature of MeCP2-targeted promoters in lymphocytes of Rett syndrome patients.

In accordance with the elevated histone H3 levels in the RTT samples, the modified versions of histone H3 investigated—histone H3 trimethylated on lysine 4 (H3K4me3), histone H3 acetylated on lysine 9 (H3K9ac) and histone H3 acetylated on lysine 27 (H3K27ac)—showed a trend toward higher levels of occupancy in the RTT samples with the only statistically significant change being an increase in H3K9ac on the myoglobin exon (data not shown).

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In order to test whether this was a reflection of a general increase in histone density, we further examined the density of histone H2B but did not find a reproducible increase in the RTT patient samples on any loci, and a slight trend toward higher histone H2B occupancy did not reach statistical significance ( Fig. 3B ).

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