Motivational disturbances and effects of L-dopa administration in neurofibromatosis-1 model mice.

General ambulatory activity was also assessed during the task ( Figure 3C ), and although Nf1 OPG mice showed a trend toward being less active than WT controls (p = 0.053), the differences were not significant ( Table S3 for all ANOVA effects).

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Differences were more striking with regard to poking into the hole containing a familiar versus a novel odorant where the CON+SAL and Nf1 OPG+LDOPA mice displayed a highly significant preference for the familiar odorant-containing hole while the Nf1 OPG+SAL mice again showed no significant preference.

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The Nf1 OPG+LDOPA mice showed a strong trend toward increased rearing to investigate the ball versus the empty area, although this comparison failed to achieve statistical significance (p = 0.064).

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