Gene expression profiling of ampullary carcinomas classifies ampullary carcinomas into biliary-like and intestinal-like subtypes that are prognostic of outcome.

PLoS One · 2013 · PMC3679143 · PMID 23776447

Europe PMC DOI

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0.1300

closest p · 2.6× alpha

0.1300

boldest claim

The sentences

did not reach statistical significancep = 0.13not close (p > 0.1)

However, the difference did not reach statistical significance (Logrank test for trend, p = 0.13).

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a strong trendno p-value reported

The biliary-like ampullary group, which showed a strong trend for shorter survival, showed increased expression of activation-specific markers in several kinase signaling pathways, including the PI3K-AKT (P-AKT Ser473, P-GSK3 Ser21, P-P70S6K T389, P-mTOR S2448, and P-FOXO3a), RAS-RAF-MEK-ERK (P-MAPK, P-MEK), and JAK-STAT (P-STAT3 S727) ( Table S2 ).

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