Breast cancer risk following Hodgkin lymphoma radiotherapy in relation to menstrual and reproductive factors.

Although the effect of treatment close to menarche was present for both those with early or normal menarche (aged <15 years) and those with late menarche (aged ⩾15 years), it was greater in the latter group; breast cancer risk reached a 15.6-fold increase (95% CI (3.92–62.22)) in those treated 0.5–2 years after a late menarche compared with those treated ⩾10 years after a normal-age menarche, which was highly significant, although based on small numbers.

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There was a significant trend of decreasing breast cancer risk with increasing time between menarche and sRT ( P trend <0.001).

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We were able to categorise patients according to time between menarche and sRT, and found a clear trend for greater breast cancer risks the closer that exposure was to menarche; this applied both to patients treated before menarche and those treated after menarche.

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