Although statistical significance was not achieved, T 4 levels also showed a trend for a reduction following treatment ( Figure 7 B, ii).
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Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity.
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A similar trend was seen with the other PredTox compounds, FP005ME and FP013NO ( Figures 4 E and 4 F), although they failed to reach statistical significance.