Vitamin D3 receptor ( VDR ) gene rs2228570 (Fok1) and rs731236 (Taq1) variants are not associated with the risk for multiple sclerosis: results of a new study and a meta-analysis.

[15] , which included 212 MS patients and 289 controls, showed a modest decrease in MS risk in homozygous for the minor allele, with an odds-ratio of 0.57(0.33–0.98), while the differences in the minor allele frequencies between MS patients and controls did not reach statistical significance.

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Finally, a meta-analysis of case-control studies showed a trend toward increased risk for MS for the dominant model of the rs731236 SNP and lack of relation of rs2228570 SNP with MS risk [13] .

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