Vitamin D supplementation for patients with multiple sclerosis treated with interferon-beta: a randomized controlled trial assessing the effect on flu-like symptoms and immunomodulatory properties.

As could be expected, mean FLS scores were higher in participants who needed analgesics, but the differences did not reach statistical significance, regardless of vitamin D dose (Figure 4 ).

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IL17 serum levels before treatment with IFN−β, as well as 3 months after treatment, could not be correlated to disease activity parameters in a cohort of 118 MS patients [ 37 ], and IL‐17 levels showed a trend towards being higher in MS patients with inactive disease compared to those with active disease in another patient cohort of 169 patients [ 38 ].

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