Comparative DNA methylation among females with neurodevelopmental disorders and seizures identifies TAC1 as a MeCP2 target gene.

J Neurodev Disord · 2013 · PMC3700820 · PMID 23759142

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hedged sentences

0.0008

closest p · 0.0× alpha

0.0700

boldest claim

The sentences

highly significantP = 0.0008actually significant

The distribution of hypermethylation and hypomethylation loci among comparison pairs was highly significant (χ 2 (2-df) = 14.17, P = 0.0008).

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approached significanceP = 0.003actually significant

However, TAC1 differential methylation approached significance in the replication analysis ( P = 0.003, FDR = 0.13), and was highly significant in both discovery and pooled analyses ( P <0.0005, FDR <0.05).

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approaching significanceP = 0.07so close (0.05 < p ≤ 0.1)

Indeed, TAC1 expression was also reduced in AUT+SEZ cingulate cortex, approaching significance ( t (5) = 2.29, P = 0.07).

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almost reached significanceno p-value reported

TAC1 gene expression changes were statistically significant in the cingulate cortex, with a trend that almost reached significance in the temporal cortex given the limited sample size; other brain regions should be evaluated in the future.

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