Conditionally-live attenuated SIV upregulates global T effector memory cell frequency under replication permissive conditions.

A similar trend was seen in animals infected with SIV-rtTAΔ nef under replication permissive conditions but did not reach statistical significance; whereas, under replication non-permissive conditions, following withdrawal of dox, only random changes were seen (Figure 3 b, c).

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Infection with either SIV-rtTAΔ nef or SIVΔ nef induced α4 + β7 + CD4 + CD95 + and CD8 + CD95 + T CM and T EM subsets although the change in CD4 + T EM cells failed to reach statistical significance the result was skewed by macaque E67, which also was an exception in the CD8 + T EM population (Figure 5 ).

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