Pregnancy outcomes following maternal exposure to second-generation antipsychotics given with other psychotropic drugs: a cohort study.

Although some of these differences did not reach statistical significance ( table 4 ), it appears that polytherapy with SGAs and other psychotropic medications may be associated with a higher risk for adverse pregnancy outcomes, compared with SGA monotherapy.

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Furthermore, a large study utilising data from the Swedish Medical Birth Register reported an increased risk of congenital malformations associated with exposure to either a typical antipsychotic or SGA; however, this finding failed to reach statistical significance after controlling for exposure to anticonvulsants. 18 Another growing concern is the increased use of multiple psychotropic medications in the treatment of mental illness.

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Our data support an increasing trend in the use of SGAs to treat a variety of psychiatric disorders, with bipolar disorder and depression being reported as the two leading indications and quetiapine being the one most commonly used.

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