Nuclear MTA1 overexpression is associated with aggressive prostate cancer, recurrence and metastasis in African Americans.

Remarkably, the difference in nuclear MTA1 overexpression between patients with localized PCa was highly significant (p < 0.001), with Caucasian Americans having higher levels of MTA1.

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In general, the main observation in the whole cohort was a strong trend of increasing nuclear MTA1 expression associated with worse pathologic parameters: localized PCa and metastatic lesions had significantly higher nuclear MTA1 levels compared with PIN.

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When stratified by Gleason score, there was a tendency for higher MTA1 staining in the recurrent compared to non-recurrent group, but the differences did not reach statistical significance.

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