Loss of ACE2 exacerbates murine renal ischemia-reperfusion injury.

As illustrated in Figure 12 , WT mice showed a trend towards increased expression of all RAS components after I/R.

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The mean value for tubular injury score after I/R tended to be higher in the ACE2 KO mice compared to the WT mice, but the difference did not reach statistical significance ( Figure 1B ).

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