Clonal dissemination, emergence of mutator lineages and antibiotic resistance evolution in Pseudomonas aeruginosa cystic fibrosis chronic lung infection.

A trend towards accumulation of resistance mechanisms was noted, from 1.4±0.58 in the first to 2.1±0.88 in the last isolates, although the differences did not reach statistical significance (p = 0.06).

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A significant trend towards increased MICs overtime to individual antibiotics was not noted, although all colistin resistant isolates occurred in the second half of the study ( Figure 2 ).

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