Similarly, APV and DNQX increased the amplitude of tonic GABA currents all cells tested, although the increase failed to reach statistical significance (tonic GABA currents in pA, ACSF: 11.3±4.1; APV+DNQX: 24.1±15.1, n = 4 cells from 3 rats, p>0.05 by t -test).
← all excerpts
A reinforcing circuit action of extrasynaptic GABAA receptor modulators on cerebellar granule cell inhibition.
2
0.0500
0.0500
The sentences
Although the average magnitude of ethanol-enhancement of tonic GABA currents in GluR antagonists was lower than that observed in ACSF (EtOH enhancement of tonic GABA currents: 187.9±27.1% p<0.05 by t -test from 10.4±3.0 pA in ACSF to 17.2±4.7pA in EtOH+ACSF, n = 6 cells from 4 rats in ACSF and 143.18±12.67% in APV+KyA, p>0.05 by t -test; tonic GABA currents 17.2±4.7pA in EtOH+ACSF, n = 6 cells from 4 rats and 18.1±2.6 pA in EtOH+APV+KyA, n = 8 cells from 5 rats, p>0.05), the difference did not reach statistical significance (EtOH enhancement of tonic GABA currents: 187.9±27.1% median = 162.36, IQR = 109.36–260.03 in n = 6 cells from 4 rats in ACSF ACSF and 143.18±12.67% median = 143.59, IQR = 105.07–181.15 in n = 8 cells from 5 rats APV+KyA, p = 0.66 by Mann-Whitney Rank Sum Test).