In a previously mentioned study from China, the OR for the highest vs the lowest quartile of soya protein intake was 0.67, with a significant trend in risk ( P for trend 0.01; Xu et al , 2004 ).
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Proanthocyanidins and other flavonoids in relation to endometrial cancer risk: a case-control study in Italy.
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Similarly, in our study, the association between isoflavones and endometrial cancer was of borderline significance in women with a BMI lower than 25 kg m −2 (OR=0.59 for the highest vs the first three quartiles, 95% CI=0.34–1.02).
This may explain the threshold effect of flavonoids in the absence of a clear trend in risk for lower levels.