Variation in psychosis gene ZNF804A is associated with a refined schizotypy phenotype but not neurocognitive performance in a large young male population.

Furthermore, we detected an individual nominally significant effect of the originally GWAS-identified SNP rs1344706 on SPQ disorganization factor (β = .022, P = .009, corrected P FDR = .081).

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34 , 22 Additionally, the genome-wide psychosis implicated marker rs1344706 was associated with the paranoid state and also showed a trend association (FDR-corrected P = .08) with the SPQ disorganization factor.

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Along these lines, we acknowledge that, several, if not all, of the identified signals in our study might still be false positives and thus the interpretation of the modestly significant associations should be conservative.

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First, at the single-marker level of analysis, highly significant association was detected between 2 out of 4 tested ZNF804A variants and the paranoid schizotypy factor derived from confirmatory factor analysis of the SPQ.

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