The zinc transporter Zip5 (Slc39a5) regulates intestinal zinc excretion and protects the pancreas against zinc toxicity.

However, elemental analyses of major organs (liver, pancreas and intestine) involved in zinc homeostasis revealed a significant increase (∼38%) in liver zinc in the knockout mice and a trend toward lower levels of zinc in the intestine and pancreas in mice fed a zinc adequate diet (ZnA), although the latter did not reach statistical significance ( Fig. 2A ).

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In these initial experiments, the data showed a trend toward reduced accumulation of pancreatic zinc in the Zip5 Panc KO mice, but variability in the data was high and the results were not statistically significant.

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