HIV-1 envelope glycoprotein signatures that correlate with the development of cross-reactive neutralizing activity.

Although some of the observed associations were marginally significant, and require confirmation in independent studies, they are in line with the hypothesis that HIV-1 Envs from individuals who develop CrNA have a more open structure, which allows for increased accessibility of bNAb epitopes, and possibly more efficient induction of bNAbs.

also in 26,082 other papers

Although these differences did not reach statistical significance they are consistent with a lower probability of glycosylation of NLS motifs, of which the presence is associated with the development with CrNA.

also in 111,027 other papers

Interestingly, early HIV-1 variants of individuals who developed CrNA showed a trend towards being more sensitive to neutralization by polyclonal HIVIg compared to early viruses from individuals who did not develop CrNA (Figure 5 ), which could be consistent with them displaying a more open Env structure.

also in 53,322 other papers