IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation.

These analyses showed similar goblet cell hyperplasia and mast cell accumulation in WT and Il9r −/− mice at days 12 and 9 (not depicted) and revealed only a modest reduction of the mucin Muc5ac and the mast cell protease Mcpt1 in Il9r −/− mice that did not reach statistical significance ( Fig. 7, G–K ).

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This analysis showed significantly reduced levels of Retnla (RELM-α) mRNA in macrophages from Il9r −/− mice, whereas Arg1 (Arginase 1) and Chi3l3 (Ym-1) levels were also lower, but the reduction failed to reach statistical significance.

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