Genetic links between post-reproductive lifespan and family size in Framingham.

The genetic correlation was large, highly significant and strongly negative in women ( r G = −0.877, P = 0.009) in a model without covariates, but not in men ( P = 0.777).

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The correlation between the quadratic term CEB 2 and lifespan was large, negative and significant in three of four models (no covariates: r G = −1.09, P = 0.003, only mother identifier as random effect: r G = −1.73, P = 0.04, only education as random effect: r G = −0.85, P = 0.01), and borderline non-significant in the model with only the father identifier ( r G = −1.61, P = 0.06).

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We also found two nominally significant SNPs that exhibited possibly non-additive effects: ss66392234 on Chromosome 12 (in HELB) and ss66500131 on Chromosome 9 (close to the pseudogene OR7E31P) ( Table 5 ).

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