Lesion load of inferior cerebellar peduncles showed a significant partial correlation with left regional mean KCC ( p = 0.029), and lesion load of superior cerebellar peduncle showed a trend towards a partial correlation with right cerebellar regional mean KCC ( p = 0.072).
Additionally, the right cerebellar cluster became significant that failed to reach significance in the original analysis using the entire fMRI data set.
A homologous area in the right cerebellum comprising Crus I and parts of Crus II showed a similar relationship between regional homogeneity and individual EDSS scores, but this trend did not reach statistical significance ( p FWE = 0.096; peak Z-score = 3.98 at voxel (x,y,z): 27, − 70, − 38).