and a negative trend was reported by Saika et al.
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The sentences
A positive trend was observed in only two studies [106] , [113] .
A total number of five studies of this tumor type were found [40] , [45] , [114] – [116] and through the established positive association, a significant trend was observed in two studies only [114] , [116] .
Borderline significant association of metastatic status and MT staining were determined (OR 1.59; 1.03–2.46), particularly in esophageal cancer.