Barely Significant
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The peroxisome proliferator activated receptor-γ pioglitazone improves vascular function and decreases disease activity in patients with rheumatoid arthritis.

J Am Heart Assoc · 2013 · PMC3886758 · PMID 24252844

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showed a trendno p-value reported
Conduit vessel endothelial‐dependent vasorelaxation (brachial artery FMD) showed a trend to improve during pioglitazone treatment but this did not reach statistical significance, nor did microvascular endothelial function (RHI) significantly improve during treatment with active drug.

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