Characterization of the vessel geometry, flow mechanics and wall shear stress in the great arteries of wildtype prenatal mouse.

Shear stress was observed to have a positive trend with age ( ρ = 0.47), but shear rate was found to be independent of age ( ρ = −0.07; p = 0.62).

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It was observed that shear stresses were statistically independent of vascular sizes ( ρ = 0.12; p = 0.40), shear rates have a negative trend with vascular sizes ( ρ = −0.39), and centerline velocities exhibited a much more significant trend with vascular size ( ρ = 0.64).

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Statistical analysis showed that velocities had a significant trend of increasing with gestational age.

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Variation of Hemodynamic Shear in Embryonic and Fetal Great Vessels with Age and Vascular Size The main finding of the current study is that wall shear stresses and wall shear rates had a weak trend with developmental age and vascular sizes, or no statistically significant trends at all; this is unlike centerline flow velocities, which had strong correlations with developmental age and vascular sizes, and unlike vascular sizes, which had strong correlation with developmental age.

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Centerline velocities and vascular sizes were observed to have highly significant increasing trends with age ( ρ = 0.72 and 0.89 respectively), which were much more significant than that of shear stress.

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