Epigenetic silencing of miRNA-9 is associated with HES1 oncogenic activity and poor prognosis of medulloblastoma.

Although it did not reach statistical significance, the analyses of miR-9-1 and miR-9-3 expression pattern in the same MB samples showed a similar inverse correlation between miR-9 expression and patient's survival ( Supplementary Figure S5C and D ).

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The lower overall survival probability of patients with low miR-9-2 expression revealed by Kaplan–Meier analysis suggests a strong trend towards prognostic significance ( Figure 6C ).

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This is highly significant because HES1, one of the main NOTCH target genes, controls cell fate decisions of the mammalian neural progenitor cells from which MBs arise ( Solecki et al , 2001 ; Pomeroy et al , 2002 ).

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