Does duloxetine improve cognitive function independently of its antidepressant effect in patients with major depressive disorder and subjective reports of cognitive dysfunction?

First, both studies noted improvements in psychomotor speed and mental processing that spanned several cognitive domains, with two of the individual tasks (RTI five-choice movement time and PRM mean correct latency) significantly improving in both studies and one (DMS mean correct latency) significantly improving in the current study and approaching significance ( P = .051) in the Herrera-Guzmán study [ 35 ].

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Affective go/no-go total commissions ( t = −1.96, P = 0.06) and immediate free recall total novel words ( t = −2.03, P = 0.06) and immediate recognition total correct ( t = 2.02, P = 0.06) measures approached significance.

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