On the other hand, no significant improvement in cardiovascular risk was observed with intensification of diabetes therapy in the Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation (ADVANCE) ( 9 ) and the Veterans Affairs Diabetes Trial (VADT) ( 10 ); in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial ( 11 ), the reduction in cardiovascular morbidity in the intensified therapy group did not reach statistical significance, due to the premature interruption because of increased mortality.
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Is glucose control important for prevention of cardiovascular disease in diabetes?
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The sentences
The Diabetes Control and Complications Trial (DCCT) showed a trend toward a 41% risk reduction of cardiovascular events in type 1 diabetes ( 6 ).