Real-time FMRI neurofeedback training of amygdala activity in patients with major depressive disorder.

The experimental group showed a significant linear trend (F(1,19) = 4.68, p = 0.024) and the control group showed a nonsignificant trend (F(1,19) = 3.84, p = 0.05).

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When the Training x ROI ANOVA was performed for groups separately, the experimental group had a significant effect of ROI (F(2,26) = 3.13, p = .025), but not Training (F(4,52) = 0.44, p = 0.39), and the ROI x Training interaction approached significance (F(4,52) = 2.24, p = 0.05).

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Within the LA in the experimental group there was a trend towards significance during PR (t(13) = 1.94, p = 0.05), and significant effects during R1, R2, R3 and TR (ts(13)>2.41, p s<0.02).

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The increase in happiness was significantly greater in the experimental compared to control group (t(19) = 2.33, p = 0.01), while the change in POMS depression between groups failed to reach significance (t(19) = 1.33, p = 0.10).

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Indeed, self-ratings of tension, anger, and irritability showed a nominal decrease in the HIPS rtfMRI-nf group that failed to reach statistical significance.

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