There was a marked trend towards a higher tumour incidence in Limk2-KO mice ( figure 9 F).
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Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation.
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When the median and mean survival times were estimated for each scoring rank, there was a clear trend from highest survival for patients scoring 6 to lowest survival for patients scoring 1 (see supplementary table S4, available online only).