Follicular nodules (Thy3) of the thyroid: is total thyroidectomy the best option?

However, the usefulness of FNAC is limited when dealing with follicular lesions presenting cellular atypia of indeterminate significance (Thy3), for which the distinction between benign and malignant lesions is ambiguous [ 11 ].

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In our study, the presence of microcalcifications and type 3 vascularization were more likely to be associated with malignancy, but the correlation did not reach statistical significance; while a hypoechoic appearance and irregular margins were highly predictive of malignancy, confirming the results of Cantisani [ 11 ].

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