Interleukin-1β attenuates myofibroblast formation and extracellular matrix production in dermal and lung fibroblasts exposed to transforming growth factor-β1.

Fibroblasts treated with IL1β already showed a trend of decreasing transgelin (TAGLN) mRNA levels in quiescent HLFa ( Fig. 3B ).

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Quantification of the % of cells stained positive for intracellular collagen after 7 days demonstrated that IL1β alone had no effect, that TGFβ1 notably induced collagen synthesis, and that the combination of TGFβ1 with IL1β showed a clear trend of decreasing collagen type I synthesis in both HDFa and HLFa ( Fig. 6D–F ).

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