Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer's disease-experimental approach and therapeutic implications.

Juice group performed better than the CTRL group, but did not reach statistical significance ( p = 0.032, Figure 2E ).

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We found that polyphenol treatment resulted in a reduced Aβ 1−42 /Aβ 1−40 ratio in the brain (One-Way ANOVA, p = 0.0112, Figure 4C ), and both Juice and Resv groups showed a strong trend of reduced ratio of Aβ 1−42 /Aβ 1−40 in the brain compared to the CTRL group ( p = 0.06 for both groups).

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