Low concentrations of the solvent dimethyl sulphoxide alter intrinsic excitability properties of cortical and hippocampal pyramidal cells.

PLoS One · 2014 · PMC3960278 · PMID 24647720

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0.0003

closest p · 0.0× alpha

0.0900

boldest claim

The sentences

highly significantP<0.0003actually significant

These differences in both input resistance (P<0.002) and sag were highly significant (P<0.0003), and remained significant when the single recording with the highest input resistance in the control group (which might be considered an outlier) was discounted.

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failed to reach statistical significanceP<0.09so close (0.05 < p ≤ 0.1)

This effect of DMSO pre-treatment, however, failed to reach statistical significance (P<0.09), possibly due to the greater cell to cell variance within the PR-L2PC population.

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a near-significant trendno p-value reported

DMSO did, however, clearly reduce membrane resistance, in CA1-PC, and a near-significant trend in this direction was also observed in PR-L2PC.

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just failed to reach significanceno p-value reported

None of the other AP parameters were significantly different although the almost 6 mV increase in action potential peak visible in the average waveform of the DMSO pre-treated group just failed to reach significance with a p-value of 0.052( Table 3 ).

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