When rs3747742 or rs9381040 are included as covariates in a conditional analysis, rs75932628 remains highly significant ( p = 1.27 × 10 −4 and p = 1.19 × 10 −4 , respectively) ( Fig. 1 , panel D), suggesting that the TREML2 and TREM2 signals are independent from each other.
2 , panel C) demonstrate a nominally significant association with CSF ptau levels.
Interestingly, according to our exome sequencing results all these variants are more common in control subjects than in AD cases, however they did not reach statistical significance with our whole-exome sequence sample size, although the three of them are more common in control subjects than AD cases ( Table 1 ).