Protective role for properdin in progression of experimental murine atherosclerosis.

At the mid-point of the experiment, atherosclerotic male LDLR −/− P KO mice showed a trend towards less weight gain.

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Levels of C3a desArg , which are generated by cleavage of plasma C3a appeared to be lower in HFD than LFD fed male LDLR −/− P WT (0.57±0.10 mg/dl vs 0.76±0.05 mg/dl) but this did not reach statistical significance ( Table 1 ).

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