Reduced bioenergetics and toll-like receptor 1 function in human polymorphonuclear leukocytes in aging.

5A, p< 0.04), reflecting the downstream effects of reduced expression of TLR1, and approached significance when stimulated through TLR4 (Fig. 5A, p=0.06).

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Mechanism of reduced signaling by PMN Reduced activation and production of cytokines by PMN in elderly adults may be significant for multiple PMN functions in vivo that depend on adhesion for recruitment and cytokines for activation of interacting immune cells [ 8 ].

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When we measured glucose accumulation in PMN using 2-NBDG, a fluorescent glucose marker, we noted somewhat lower levels of glucose in PMN of older adults at baseline that did not reach statistical significance (Fig 5B, ns).

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