Evaluation of a human BCG challenge model to assess antimycobacterial immunity induced by BCG and a candidate tuberculosis vaccine, MVA85A, alone and in combination.

Levels of BCG Recovered Were Lower in Groups With Previous BCG Vaccination Enumeration of BCG by solid culture showed a trend toward a lower median colony-forming unit count in the previously BCG-vaccinated groups, with a statistically significant 0.5-log reduction in colony-forming unit count between group A (naive) and group D (BCG–MVA85A; P = .02, Mann–Whitney U test; Figure 2 ).

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The same trend was observed when ELISpot responses were correlated with colony-forming unit counts by culture but did not reach statistical significance at any time point (data not shown).

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