Functional assessment of pharmacological telomerase activators in human T cells.

Although not discernible in Figure 2 A,B, there was a slight trend in upregulation of telomerase activity in the HTA (10 −6 gm/mL) treated cultures for some donors during a second stimulation, but only in two out of six donors did this reach statistical significance.

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By contrast, HTA, had no effect on the telomerase activity following first stimulation, and caused only a modest 1.3-fold increase following second stimulation, which did not reach statistical significance ( Figure 1 A,B).

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When results of all six cultures were evaluated, the HTA-mediated effect failed to reach statistical significance.

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