Common breast cancer risk variants in the post-COGS era: a comprehensive review.

Breast Cancer Res · 2013 · PMC3978855 · PMID 24359602

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highly significantno p-value reported

For the FGFR2 genomic region, SNP rs2981579 (10q26.13, FGFR2 c.110-12117 T > C) was chosen (this SNP is in linkage disequilibrium at r 2 <0.6 with the three SNPs described above) and showed highly significant associations with a risk of breast cancer.

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did not reach statistical significanceno p-value reported

In all, the authors estimated that ~14% of familial breast cancer risk in people of European descent is explained by these 67 established loci, with an additional ~14% of the familial risk explained by SNPs that showed associations in the COGS study but did not reach statistical significance.

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showed a trendno p-value reported

The SNPs rs2380205 (10p15.1, intergenic, 2.6 kb 5′ to GDI2 ) and rs1045485 (2q33.1, CASP8 p.Asp302His) showed a trend towards association, and the SNPs rs2284378 (20q11, RALY c.-93 + 6158 T > C) [ 63 ] and rs1982073 (19q13.2, TGFB1 p.Pro10Leu) [ 23 , 24 , 44 ] were not tested on the iCOGS array.

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