Label-free proteomics identifies Calreticulin and GRP75/Mortalin as peripherally accessible protein biomarkers for spinal muscular atrophy.

Both GRP75/Mortalin and Calreticulin showed a trend towards increased levels in the small cohort of SMA patients compared to controls (Figure 3 ).

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GRP75/Mortalin levels increased on average by 50% compared to controls, although the considerable variability between individuals and low sample size meant that this difference did not reach statistical significance (Figure 3 B).

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