Positioning of APOBEC3G/F mutational hotspots in the human immunodeficiency virus genome favors reduced recognition by CD8+ T cells.

PLoS One · 2014 · PMC3982959 · PMID 24722422

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a significant trendno p-value reported

If this reflects a significant trend in vivo , then adaptation by HIV to enrich sequences that are favored for mutation by A3G/F (A3G/F hotspots) in portions of its genome that encode immunogenic CD8 + T cell epitopes would favor CTL escape.

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a strong trendno p-value reported

We observed a strong trend.

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