Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver.

On the other hand, only 35% of the genes whose expression was reduced significantly in the Rapa + DR mice showed a non-significant decrease in the DR mice; almost 60% of the genes significantly reduced in Rapa + DR mice showed a trend toward reduced expression in mice fed only Rapa.

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When we scrutinized the list of genes of the Rapa + DR group and compared the list to either the DR or Rapa gene list, we observed that the majority of the genes that appear as new genes in the combined treatment were also altered in the same direction by DR or Rapa but did not reach statistical significance; only a handful of genes appears as a new genes [e.g., transcobalamine (Tcn2), sulfiredoxin1 (Srxn1), CD81 antigen (CD81)].

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