MicroRNAs shape circadian hepatic gene expression on a transcriptome-wide scale.

The effect, however, did not reach statistical significance (p=0.197) ( Figure 3D,E ).

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Interestingly, our experiments showed a trend towards period lengthening in knockout liver explants with a period that was on average 41 min longer than in controls.

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Nevertheless, both the amplitude decrease and the phase delay were individually highly significant, as also shown by permutation tests in which we randomly reshuffled either the timepoints of the original data or the Dicer KO/control assignments on a genewise basis, followed by analyses of rhythm parameters.

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