Future Trends in the Pharmacogenomics of Brain Disorders and Dementia: Influence of APOE and CYP2D6 Variants

Pharmaceuticals (Basel) · 2010 · PMC4034082

Europe PMC

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a clear trendno p-value reported

APP/PS1 mice treated with either 2.5 mg/kg/d or 33 mg/kg/d of GW3965 showed a clear trend toward reduced amyloid burden in hippocampus and whole brain, whereas treated APP/PS1 mice lacking ABCA1 failed to display reduced amyloid load in whole brain and showed trends toward increased hippocampal amyloid.

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highly significantno p-value reported

Haplotype analysis showed highly significant association of seven COMT marker haplotypes with SCZ, and allelic associations of two SNPs (rs4633, rs4680) with drug response were also found.

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showed a trendno p-value reported

The complete re-sequencing of the 56 mtDNAs belonging to H5 revealed that AD patients showed a trend towards a higher number of sporadic mutations in tRNA and rRNA genes when compared with controls. 2.2.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.