Protein flexibility facilitates quaternary structure assembly and evolution.

A clear trend is observed for nearly all species.

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Although we observed a strong trend for the evolutionarily more recent subunits of protein complexes to be more flexible, it is possible that this could to some extent reflect a general tendency for evolutionarily more recent proteins to be more flexible.

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If there is a tendency for evolutionarily related proteins to be more flexible when they are part of complexes with more nonhomologous subunits, then we would expect these values to show an increasing trend.

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Most strikingly, we observe a highly significant tendency for the subunits of cyclic and asymmetric complexes to be more flexible than those forming twofold dimeric or dihedral topologies.

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