Importance of cardiovascular disease risk management in patients with type 2 diabetes mellitus.

In type 1 diabetes mellitus, DCCT (Diabetes Control and Complications Trial) showed a trend towards a lower risk of CV events with intensive glucose control, but the number of events was small and the result was not statistically significant. 64 However, EDIC (Epidemiology of Diabetes Interventions and Complications), a 9-year follow-up of the DCCT cohort, showed that participants who wer

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The same trend was demonstrated for patients with diabetes, although it did not reach statistical significance, possibly because of limited study power. 61 Diabetes guidelines universally recommend that all patients should be advised not to smoke, and that smoking-cessation counseling and other forms of treatments should be included as routine components of diabetes care. 25 , 27 Glucose control In the context of elevated blood glucose, the function of the vascular endothelium is altered in ways that promote atherosclerosis (reviewed in Bornfeldt and Tabas 62 ).

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