Improvement of spinal non-viral IL-10 gene delivery by D-mannose as a transgene adjuvant to control chronic neuropathic pain.

J Neuroinflammation · 2014 · PMC4046049 · PMID 24884664

Europe PMC DOI

hedged sentences

0.0900

closest p · 1.8× alpha

0.0900

boldest claim

The sentences

did not reach statistical significanceP = 0.09so close (0.05 < p ≤ 0.1)

While spinal IL-10 increases contralateral to the CCI did not reach statistical significance ( P = 0.09), these data suggest that pretreatment with D-mannose improves transgene uptake for sustained pain suppression acting as a complementary factor for stimulating peri-spinal immune cells to respond to transgene material.

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a strong trendno p-value reported

While D-mannose pretreatment followed by pDNA-IL-10 abolished bilateral spinal cord IL-Iβ IR, it significantly increased ipsilateral IL-10 IR in both the spinal cord and the DRG, while generating a strong trend toward IL-10 IR in the contralateral spinal cord and DRG.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.