Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes.

Breast Cancer Res · 2012 · PMC4053108 · PMID 23036105

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closest p · 2.2× alpha

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failed to reach statistical significanceP = 0.11not close (p > 0.1)

For instance, despite a strong predictive association of Nuc-Stat5a in CSS analyses in Material VI, TTR in Material VI failed to reach statistical significance by univariate log-rank ( P = 0.11) and multivariate Cox regression models ( P = 0.087), whereas univariate Cox regression in Material VI indicated a twofold significant increased risk of breast cancer recurrence ( P = 0.033).

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did not reach statistical significanceP = 0.11not close (p > 0.1)

Univariate Cox regression also revealed a significant increased risk of breast cancer recurrence in these patients (TTR univariate Cox regression HR = 2.15 (1.06, 4.35); P = 0.033; n = 55), although despite a clear separation of Kaplan-Meier curves, log-rank analysis did not reach statistical significance (TTR log-rank P = 0.11; n = 71; Figure 3D ).

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