Effect of selenium on markers of risk of pre-eclampsia in UK pregnant women: a randomised, controlled pilot trial.

There is a near-significant difference between the effect in the bottom quartile and the rest (ratio for the lowest quartile compared with the other quartiles: 0·67, 95 % CI 0·45, 1·00; P = 0·051).

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In participants in the lowest quartile of Se status at baseline, treatment with Se significantly lowered the concentration of sFlt-1 ( P = 0·039) and halved the ratio of sFlt-1:PlGF, though the latter effect did not quite reach significance ( P = 0·066); however, in all participants taken together, Se treatment had no effect on sFlt-1 concentration, PlGF concentration or sFlt-1:PlGF ratio.

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Soluble vascular endothelial growth factor receptor-1 by quartile of baseline selenium status Given the significant effect of Se treatment on sFlt-1 concentration in women in the lowest quartile of Se status at baseline, we decided to determine whether the effect showed a trend by quartile.

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As expected, the effect of Se treatment on the incidence of either outcome failed to reach significance (data not shown).

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However, when the two outcomes were combined on the basis that there may be some continuity between the conditions ( 60 – 63 ) , and when the analyses were adjusted for baseline Se concentration and haematocrit, Se treatment significantly reduced the odds of having either pre-eclampsia or PIH in all participants (OR 0·350, 95 % CI 0·126, 0·974; P = 0·044) and with near significance in those in the bottom third of Se status at baseline ( Table 6 ), with large treatment effects.

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